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The study also found that while Fragment 176-191 induced rapid weight loss in obese mice by raising levels of beta(3)-AR RNA (ADRB3), it had no such effect in lean mice

Consequently, Nb1053 has been radiolabeled with 18 F, resulting in a radioconjugate excreted via the hepatobiliary system, that prevents renal accumulation without compromising tumor uptake [99,100,101,102,103,104,105,106,107,108,109]