foxo4-dri peptide senolytic animal model 2023 The disordered p53 transactivation domain is the target of FOXO4 and the compound FOXO4 - an overview |
FOXO4 an overview ScienceDirect Topics FOXO4 DRI Averix Labs Peptide inhibitors targeting FOXO4 p53 interactions and inducing senescent cancer cell specific apoptosis bioRxiv The FOXO4 peptide in a DRI conformation (D amino acids in a retro reversed sequence), henceforth named FOXO4 DRI, competes with FOXO4 for p53 binding in a dose dependent manner and doing so with higher affinity.
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