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These limitations reinforce the urgent need for neuroprotective strategies that can preserve neuronal integrity, delay progression, and extend the functional lifespan of patients [18, 19]

Currently, magnetic resonance imaging (MRI) techniques are highly sensitive, and MRIs show iron accumulation in the nucleus of the pallidum, caudate and chiasmatic nuclei, and also in specific cortical region (van Duijn et al., 2017)