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However, because excretion of vitamin B12 in the stool is proportional to B12 body stores, B12 deficiency develops more slowly in persons han in persons with no intrinsic factor or with malabsorption 22b.1.4 Deficiency of vitamin B12 in humans The common consequence of B12 deficiency is a cellular deficit in one of the coenzyme forms of B12 which affects cellular metabolism, methylation and mitochondrial metabolism: such deficits may pass from a stage of subclinical deficiency through to severe, clinical forms

If they do, this would also add evidence that this NNMT inhibitor improves muscle performance through increasing NAD+ levels

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