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While these therapies have shown significant success, they come with certain limitations, mainly associated with the development of resistance and side effects

Panou DA, et al

373 Pathway inhibitors: targeting CSC-specific signaling pathways CSCs rely on key developmental signaling pathways, including the Notch, Hedgehog, Wnt, and PI3K/AKT/mTOR pathways, to sustain their self-renewal, survival, and differentiation capacity