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If conditions are not favorable for thyroid hormone activity, such as extreme stressors like hibernation, starvation, and sepsis, then T4 is converted instead to reverse T3 (rT3) by D3, which is induced by the stress condition and localized to the outer plasma membrane of the cell

Parasite GS-specific polyclonal sera were used at 1:250 dilution

Similarly, being bound to pyrrolidine and ethyl groups did not cause much change in inhibition (K i : 54.39 4.85 nM for compound 26