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1 Introduction The prevalence of neurodegenerative diseases is growing, largely because of the rise in the elderly population in recent years (Wang and Michaelis, 2010)

Blocking autophagic flux in neutral pH condition or further impairing proteasome function with proteasome inhibitors, significantly aggravated PPI cytotoxicity by worsening protein degradation ability

PMID: 40263302 Cell Death Dis HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion