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Indication: Vitamin B12 is indicated for debilitation by acute or chronic metabolism disorders that result from poor nutrition, inadequate management or disease (e.g

Across all six studies, the safety findings were consistent: no serious adverse events, no immunogenic responses, no changes in IGF-1, no glucose or insulin disruption

In the UK, the NHS says it is more common in older people, affecting around 1 in 10 people aged 75 or over and 1 in 20 people aged 65 to 74. Sources:

Moreover, smooth-fitting curve analysis identified a threshold effect: below 358.7 pg/mL, each 10 pg/mL increase in vitamin B12 was associated with a 4.4% increase in clinical pregnancy rate (OR = 1.04, P = 0.03), beyond which no further benefit was observed