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The metal-binding affinities of the individual Cu(II) proteins, determined by different methods vary largely as their accurate estimation is a subject to a number of pitfalls and complicating factors 29

doi:10.1124/jpet.102.037481

Once glutathione levels collapse, the cells experience "sulfhydrative stress." Without this master antioxidant to buffer the damage, free radicals begin to attack and degrade the mitochondria, further crippling cellular energy production

Common complications of polycythemia vera Polycythemia vera complications include: ThrombosisClots represent the most serious risk, causing heart attack, stroke, or pulmonary hypertension