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Here we treated HFD-fed mice, a commonly used AMD model, with MZP for 4 weeks and found that MZP counteracted the HFD-induced effects via decreasing the cholesterol accumulation, upregulating the expression of cholesterol metabolism and trafficking genes, and suppressing the oxidative stress and inflammation in mouse RPE and liver as well as modulating the composition, diversity, and metabolic pathways of gut microbiota

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