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Similar to previous studies in salivary glands (Avila et al , 2009), we found a 10 Gy dose induces DNA damage and cell cycle arrest, as well as reduces cell proliferation in the SLG in the first day following IR, as shown by a substantial increase in the proapoptotic gene Bax and the cell cycle inhibitor Cdkn1a (p21) (Fig EV4A) and a reduction in transcript levels of the cell proliferation marker Mki67 (Fig EV4A)

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