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In mice, glutaredoxin 1 is associated with suppression of airway neutrophil influx and pro-inflammatory cytokine release as well as decreased activation of NF-B in the lung (6, 49)

Western blots were documented using the ChemiDoc gel imaging system (Bio-Rad)

The primary analysis was conducted using the Inverse Variance Weighted (IVW) method, and was further corroborated by an array of statistical techniques including MR-Egger, Weighted Median, Weighted Mode, cML-MA, ConMix, MR-RAPS, and DIVW to ensure robustness and reliability of the findings.Heterogeneity was evaluated using Cochrans Q test, horizontal pleiotropy was assessed through MR-Egger regression, and leave-one-out analyses were performed to validate the causal relationships

Immaturity of the intestinal barrier function, limitations in production of AMPs, and ineffective response and action of epithelial cells and phagocytes place the infant at risk for infection in the neonatal period (25, 26)