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Proc Natl Acad Sci USA (1987) 84:30048

3.1 RONS 3.1.1 NMs Visualize RONS to Evaluate Macrophage Activity ROS are considered a series of chemically active substances generated from intracellular oxygen through electron transfer, primarily including hydrogen peroxide (H 2 O 2 ), hydroxyl radical (OH), hypochlorous acid (HOCl), and superoxide anion (O 2 ) [78]

Experimental studies have shown that inhibition of miR-34a in mice fed an HFD increases PPAR expression and AMPK activation, which promotes fatty acid -oxidation and reduces TG accumulation in the liver [300]

These compounds help protect cells from oxidative stress, which can accumulate during intense training