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This is well illustrated by the velocity equation for the CBS reaction, the first step in the transsulfuration pathway: The first factor is simply Michaelis-Menten kinetics for the CBS reaction that uses homocysteine (Hcy) and serine (Ser) as substrates

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McCoy LF, Scholl PF, Schleicher RL et al (2005) Analysis of aflatoxin B1-lysine adduct in serum using isotopedilution liquid chromatography/tandem mass spectrometry