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The key principles include: Protein Priority: Maintain 1.6-2.2 g/kg protein to preserve lean mass, especially when appetite is suppressed by GLP-1 agonists

To treat nocturia due to reduced bladder capacity, treatment with antimuscarinics (preferably solifenacin, trospium or darifenacin due to their lower risk of cognitive side effects) should be considered instead

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When used as maintenance therapy, Velcade may be administered weekly or less frequently, such as once every 2 weeks, with similar or longer treatment periods