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As part of the process, it recycles a compound called homocysteine, which prevents levels from building up

[DOI] [PMC free article] [PubMed] [Google Scholar] Bao M

Metabolic proteins with relative expression changes of two-fold or greater were connected to their location in the soluble or insoluble fraction by red or blue edges (up or down, respectively)

And it's really strongly associated with insulin resistance and muscular dysfunction in people with metabolic disease or people with type two diabetes or obesity