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The peptide natural decline with age is noteworthy

J Alzheimers Dis 2015;45:985-1000

For example, STAT4 regulates signaling from IL-12 and IL-23 receptors in T-cells and from IFN receptor in monocytes and NK cells, while IRF5 is a transcription factor in the type 1 interferon pathway, and CD247 encodes for a subunit of the T-cell receptor and modulates T-cell activation [reviewed in Romano et al