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AST/Bex also upregulated the expression of ABCA1, LRP1, and/or APOA-I, thereby facilitating cholesterol efflux partially through PPAR/RXR activation, and downregulated cholesterol biosynthesis and esterification

We have created this scoring system, as no such method was previously reported in the literature

Nevertheless, by pooling the data, we were able to construct an accurate model based on, respectively, more than 600 and more than 300 PK and PD data points

In thalassemia, unstable globin chains and excess free iron generate reactive oxygen species, which damage red blood cell membranes and shorten their lifespan