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10.1126/science.1261821 Science 30 ChenX.MarreroH.FreedmanJ

Human GWAS meta-analyses have found novel candidate genes that, when mutated, may be associated with disc degeneration, including PARK2 (Williams et al., 2013) and CHST3 (Song et al., 2013)

Vitamin B12 deficiency symptoms The most common vitamin B12 deficiency symptoms include (2, 11): Pale skin Low energy Shortness of breath Palpitations Tingling or numbness in hands and/or feet Lower sense of position of body parts Lower ability to feel vibrations Abnormal walking pattern Muscle weakness Loss of concentration Poor memory Confusion Depression Vision problems Insomnia Impotency Poor bowel or bladder control Constipation Flatulence Sore tongue Appetite loss Loss of mental or physical drive Can I have a vitamin B12 deficiency without any symptoms

Extended modulation of these pathways could potentially influence hormonal regulation, mood, and neurological function