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A 2025 systematic review in the International Journal of Dermatology documented liver function abnormalities in approximately half of IV-treated participants at high doses, which is why DermaVue restricts treatment to evidence-based clinical doses of 400 to 1200 mg with mandatory hepatic monitoring

The cell contains millimolar concentrations of GSH (up to 10 mM) that is maintained in this reduced form by a cytosolic NADPHdependent reaction catalysed by glutathione reductase

New mutations may occur frequently, leading to a heterozygous state in which two or more mtDNA sequence variants (i.e., wild type and one or more mutants) coexist

These cells enable the generation of cerebral organoids (COs) to study this disorder and its underlying cellular and mitochondrial mechanisms in a more physiologically relevant environment