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Most compounds that target tumor metabolism (methotrexate, 5-fluorouracil) fail to distinguish between tumor tissue and rapidly differentiating epithelial tissue (skin, bone marrow), 4,322 whereas therapies targeting the specific amino acid dependence of tumor cells are cell-selective, such as leukemic blasts that are selectively dependent on Asn, the use of bacterial-derived ASNase in pediatric ALL has significantly improved the cure rate

While long-term dialysis treatments can be used as a temporary solution for people awaiting transplants or those who are not fit for the transplant operation, it is crucial to consider the transplant option early

High- and low-risk categories of patients with TNBC were established with subsequent categorization performed according to their median risk score

1.5 Oxidative stress Lately, oxidative stress has been recognized as a central factor underlying autoimmune and inflammatory diseases