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However, these direct and indirect approaches, referred to as BDNF-based therapies, still face many other challenges

Of these, CXCL8 and CCL26 are pre-stored in the classical WPB compartment and released upon inflammatory or thrombotic stimulation, while CXCL1 and CCL2 are stored in distinct, yet equally responsive, vesicular compartments (Utgaard et al., 1998