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TMAO Metabolism Choline, L-carnitine, betaine, and other choline-containing compounds are the major nutrient precursors of gut microbe-dependent TMAO, a pro-atherogenic metabolite (Wang et al., 2011

In fact, many genes coding for sulfate transporters and for enzymes of the primary assimilation pathway are induced at the transcriptional level by sulfur deficiency whereas reduced sulfur-containing compounds, such as hydrogen sulfide (H 2 S), cysteine, S-adenosyl-methionine (SAM) and glutathione, exert inhibitory effects at the post-translational level (Kopriva and Koprivova, 2004

We have already seen examples: transplanting microbiomes from patients into mice to induce disease features, or adding/removing single species to gauge their impact on pathology

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