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Covalent inhibitors of nicotinamide N-methyltransferase (NNMT) provide evidence for target engagement challenges in situ

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Common symptoms include: Persistent fatigue and weakness Pale or jaundiced skin Heart palpitations and shortness of breath Nerve problems such as numbness or tingling Cognitive disturbances such as memory loss Glossitis and mouth ulcers High homocysteine levels, leading to cardiovascular issues Given the severe symptoms associated with Vitamin B12 deficiency, timely and effective treatment becomes essential