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The organized matrix of bone marrow (BM) facilitates the proliferation and differentiation of hematopoietic cells, supported by stromal components including fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, and endothelial cells [32]

The Cd selectivity of this protein and the rapid up-regulation of its gene upon Cd exposure suggest that its Cd-specific function is dedicated to detoxifying this metal, with an important contribution from digestive gland cells (Vega et al