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doi: 10.1038/s41569-020-0340-9 187 LinRZImGBLuoACZhuYHongXNeumeyerJet al

The lmFit function was used to fit a linear model to the normalized -values for each CpG site, and empirical Bayes moderation was applied using the eBayes function to improve variance estimation and enhance the stability of statistical inference