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Gemcitabine plus platinum-based chemotherapy in combination with bevacizumab for kidney metastatic collecting duct and medullary carcinomas: results of a prospective phase II trial (BEVABEL-GETUG/AFU24)

The microalga supplementation also increased MIF which indicates that it is a potent antioxidant agent since the gene MIF encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation which plays roles in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoidsa mechanism substantial for protection against environmental triggered stress at the cellular level [31]

The p70S6 kinase is a protein, when phosphorylated, is known to induce protein synthesis at the ribosome and has been used as a marker of activation by mTOR, leading to pro-survival signaling activation 34

Purification from nuclear extracts was performed according to Nakatanis protocol with some modifications 49