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Supplementation of folic acid is also important for patients on certain medicines, such as methotrexate for rheumatoid arthritis, as these medications can reduce folate in the body

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Generally, the schedule for vitamin B 12 replacement is 1 mg daily for a week or 1 mg 3 times a week for 2 weeks, followed by 1 mg per week for 1 month, and then 1 mg per month as maintenance dose.9 Around 1% to 5% of free vitamin B 12 can be absorbed along the entire intestine by passive diffusion