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Another aspect of the invention pertains to small molecule quinoline derived cations of Formula IA, wherein: the cation of Formula IA includes two or more non-hydrogen substituents, and wherein: R 5 is H or NH 2 , R 6 is H or F

It significantly induced DNA strand breaks in HepG2 cells with hamster S9-mix only, with a mfc of 3.9 at 0.25 mM

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In FM, melatonin has been shown to improve sleep quality, pain levels, and the pain threshold by enhancing the descending endogenous pain-modulating system [63]