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High activity of NNMT is also correlated with lower levels of glucose transporter 4 (GLUT4), which is vital for glucose uptake from the bloodstream into fat and muscle cells

IDH1 R132H enzymatic inhibition The inhibitory activity of the off-DNA compounds against IDH1 R132H were assessed by absorbance assays similarly to reported procedures 56 , using IDH1 R132H purified in-house as described above