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Safety of combining radiotherapy with immune-checkpoint inhibition

Proc Natl Acad Sci U S A 95:1171511720 Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, Schumacker PT (2000) Reactive oxygen species generated at mitochondrial Complex III stabilize hypoxia-inducible factor-1 during hypoxia: a mechanism of O 2 sensing