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The mechanisms underlying this age-related NAD+ depletion involve multiple factors, including increased consumption by DNA repair enzymes, reduced biosynthesis, and enhanced degradation by CD38 and other NAD+-consuming enzymes

To facilitate understanding, we comprehensively review current literature on possible underlying pathophysiological mechanisms and treatment strategies for managing abdominal pain in constipation

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Ferroptosis and cancer BAP1-mediated regulation of ferroptosis The BAP1 gene, associated with the suppression of tumors, encodes a nuclear deubiquitinating (DUB) enzyme that forms the polycomb repressive deubiquitinase (PR-DUB) complex