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The study protocol and procedures were in accordance with the ethical standards outlined in the Declaration of Helsinki and its later amendments (21) and approved by the ethical committee of IUMS (ethical code: IR.MUI.REC.1395.3.929)

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But inhibitors to different enzymatic cleavage of other substrates are still needed

A major limitation of many studies investigating the effect of KD on the skin is the lack of randomization, which significantly reduces their scientific value