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In addition to these reforms to opioid treatment standards at 42 CFR part 8 codified by SAMHSA, there have been recent activities under the Medicare in the PFS, and through other CMS programs, that have addressed the social determinants of health (SDOH), which often affect the diagnosis and treatment of a patient's medical problem

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Preclinical characterization and IND-enabling safety studies for PNT001, an antibody that recognizes cis-pT231 tau

However, such immunosuppression brings its own risks, including infection, reduced GvL and disease progression