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Vitamin E in creams Can significantly improve hot flashes, fatigue, de- GLA can be used topically in the pression, and vaginal irritation25 Calcium plus vagina to reduce itching and vitamin D irritation Can be effective in reducing hot flashes, vaginal ir- As 24 g evening primrose oil ritation, and mood swings26 Reduces loss of mineral content of bones and 8001000 mg calcium

Moreover, uracil, n-oleoylethanolamine, asymmetric (ADMA) and symmetric (SDMA) dimethylarginines (protein degradation residues), palmitoylglycerol (active metabolite) and pseudouridine (nucleotide metabolism) were depleted in T4 only, whereas -muricholic acid (bile acid) was depleted in T5

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