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found that apoptosis is caused by the release of cytochrome c from the mitochondria, leading to the cleavage of caspase 3 and PKC and finally DNA fragmentation (Latchoumycandane et al., 2005)

NAC can ameliorate ribavirin therapeutic index, either by declining its toxicity or even allowing the use of a lower dose of the ribavirin, a previous report was conducted on mice illustrated that administration of NAC combined with antiviral therapy had a better response, both have a diverse mechanism of action that improves the outcome and reduce the severity of illness [71]

However, silver was replaced by safer therapies in the recent decades