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Compared with a low-Se diet (0.05 mg/kg), a high-Se diet (1.5 mg/kg) maintained postischemic plasma GSH levels and GPX activity and improved myocardial infarct size and postischemic mean arterial blood pressure in rats [115]

Optical coherence tomography angiography assessment of the macular capillary plexus after surgery for macula-off rhegmatogenous retinal detachment

KDM3A or KDM4C suppression resulted in robust DNA damage response and aggravated cellular senescence, whereas KDM3A or KDM4C overexpression promoted heterochromatin reorganization and decreased DNA damage response [106]

However, if essential reactions are eliminated or the directionality of these reactions are changed without proper review, the behavior of the metabolic model might shift away from the known biological phenomena of the cell