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Dosing information Usual Adult Dose for Pernicious Anemia: Initial dose: 100 mcg intramuscularly or deep subcutaneous once a day for 6 to 7 days If clinical improvement and reticulocyte response is seen from the above dosing: 100 mcg every other day for 7 doses, then: 100 mcg every 3 to 4 days for 2 to 3 weeks, then: Maintenance dose: 100 to 1000 mcg monthly Duration of therapy: Life Comments: Administer concomitant folic acid if needed

Years ago, different insulin concentrations were common like U20, U40, or U80 but they often led to confusion and dosing errors

Adults typically need 2.4 mcg per day (which goes up to 2.6 and 2.8 mcg per day if pregnant or breastfeeding, respectively)