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Overall, the oral route dominated the field, accounting for the largest proportion of publications (see Figure 10) and showing a sharp and sustained rise in interest over the past decade

Jacob S, Nair AB, Shah J

Aldosterone Receptor Blockers Spironolactone and eplerinone, aldosterone receptor blockers, used in the treatment of heart failure in humans, are thought to be effective by blocking the remodeling effects of aldosterone