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In clinical settings, such limitations have driven a shift toward multi-targeted therapies that offer improved efficacy and reduced resistance [3]

The term hepatic failure denotes a clinical condition in which the biochemical function of the liver is severely, and potentially fatally, compromised

Antitumour and gene knockdown effect in orthotopic model We created orthotopic pancreatic tumour models to mimic tumour microenvironment that most resembled the in vivo scenario, and evaluated the antitumour effect of siRNA by systemic administration (30 g siRNA per mice equivalent) for six times (Fig