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202 Thus, natural products may serve as an additional resource for the discovery of new GPX4 inhibitors

10.1371/journal.pone.0169622 153 PiretJ

Although the degree of inflammation in OA is generally lower than in rheumatoid arthritis, synovial tissue can still exhibit marked hyperplasia and inflammatory cell infiltration ( Accompanying inflammation and mechanical damage, oxidative stress and multiple forms of cell death are deeply involved in the molecular mechanisms driving OA progression ( Figure 1 )