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While most intracellular glutathione is in a reduced state (GSH) with approximately 1% as an oxidized form (GSSG), this proportion can decrease in response to a variety of cellular stressors, including heavy metals, high glucose concentrations, poor nutrition, heat shock, reactive oxygen and nitrogen species, cigarette smoke, and other toxins including persistent organic pollutants

The major studies relating viral infection and glia cells have been developed in HIV-1 model infection