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Husted, A

These findings suggest that surpassing a threshold concentration of AA in the hypothalamus may be necessary to engage central mechanisms that enhance its therapeutic potential, and dosing strategies should aim to achieve effective hypothalamic engagement while remaining feasible and safe for clinical application

Whole-genome CRISPR screening has further validated that lipoylation modifications are central to copper-induced cell death (cuproptosis), with DLAT aggregation serving as a crucial molecular hallmark (159,160)

In the normal pancreas, acinar cells use amino acids to synthesize digestive enzymes, and ductal cells are mainly responsible for the transport of peptides and hormones