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3 Interactions of autophagy with the cGAS-STING pathway 3.1 cGAS The interplay between autophagy and cGAS occurs through (i) cGAS-Beclin-1 interaction that promotes autophagic degradation of cytosolic dsDNA, (ii) cGAS-LC3 interaction that promotes micronucleophagy, and (iii) degradation of cGAS through p62-mediated selective autophagy ( Figure 3 )

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Hence, the optimization of potential therapeutic uses of melatonin in psychiatric disorders must encompass the specificities of an integrative molecule inextricably linked to entrainment, metabolism, immunity, neurotransmission, and cell homeostasis