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However, the annatto plant ( Bixa orellana ), a shrub native to South America, is a profound biological exception

doi: 10.1038/labinvest.2009.119 128 HondaMKubesP

The muscles may ache and become tender to touch

Together, these shared mechanistic patterns suggest that ferroptosis represents a fundamental regulatory node in host-pathogen interactions, which may be commonly exploited by diverse pathogens to modulate infection outcomes