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Symptoms of the disease include: continual tiredness confusion memory loss mood swings erratic behaviour Left untreated causes irreparable damage to the central and peripheral nervous system

For most patients with vitamin B12 deficiency, high-dose oral supplements are as effective as intramuscular injections at raising serum B12 levels and resolving symptoms

This process is accompanied by the activation of NOD-like receptor thermal protein domain-associated protein 3(NLRP3) inflammatory vesicles and the formation of neutrophil extracellular trapping networks (NETs), which exacerbate corneal epithelial damage and persistent microbial infection

PMID: 40954252 Disulfiram purchased from MedChemExpress