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286,287 This indicates that therapeutic targeting of STAT-6 affects different pathways

However, whereas one published case report noted a response of RMC to anti-PD-1 immune checkpoint therapy (ICT) with nivolumab 11 , two additional case reports suggested poor efficacy of nivolumab alone or in combination with anti-CTLA-4 blockade using ipilimumab 12

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This might be due to blocking active microglia, as shown in mouse models of ALS ( 6.5.4 Neuropathic pain BV also helps to alleviate neuropsychiatric problems