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Blood samples were collected in EDTA tubes and as dried blood spots (DBS) on Whatman 903 filter paper

Trastuzumab deruxtecan (T-DXd), which conjugates a topoisomerase I inhibitor to the trastuzumab scaffold, demonstrates high efficacy across HER2-expressing breast, gastric, and gynaecologic tumours

For the [U 13 C]glutamine isotopic tracing analyses (Fig 2E), MYC liver tumors were generated through hydrodynamic transfection of 8weekold FVB/n male mice (Taconic Biosciences) (Fig EV3), as described previously 28

When mitochondria arent able to produce enough energy that your body needs, it affects how your organs function