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These rechallenged mice rejected the implanted EG7 cells with a long-term survival, while tumor growth was aggressive in naive mice (Figure 4S)

IAC-S010759(OPi) has same functional backbone but has been attenuated conduction (Vashisht Gopal et al., 2019), a directed CI inhibitor, was shown to significantly inhibit the growth of melanoma models with multiple MAPKi resistant BRAF mutation in vivo at tolerated doses, and strongly inhibited proliferation and induced apoptosis in OXPHOS-dependent brain cancer and acute myeloid leukemia (AML) models

Summary Keywords edible mushrooms, health benefits, nutritional value, phytochemicals, industrial usage Citation Noreen S, Sultan H, Hashmi B, Aja PM and Atoki AV (2025) Mushroom marvels: understanding their role in human health

The two studies proved the synergistic effect and mechanism of the two drugs at therapeutically achievable doses on non-APL AML cells