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N Engl J Med (1983) 309:76470

Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice

doi:10.1016/j.csbj.2020.05.004 45

Thats why many experts recommend dividing your dose throughout the day, for example, 600 mg in the morning and 600 mg in the evening, to keep steady antioxidant levels